quinta-feira, novembro 21, 2024
HomeNanotechnologyTargeted intervention in nerve–cancer crosstalk enhances pancreatic cancer chemotherapy

Targeted intervention in nerve–cancer crosstalk enhances pancreatic cancer chemotherapy


  • Mizrahi, J. D., Surana, R., Valle, J. W. & Shroff, R. T. Pancreatic cancer. Lancet 395, 2008–2020 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Neoptolemos, J. P. et al. Therapeutic developments in pancreatic cancer: current and future perspectives. Nat. Rev. Gastroenterol. Hepatol. 15, 333–348 (2018).

    Article 
    PubMed 

    Google Scholar
     

  • Wood, L. D., Canto, M. I., Jaffee, E. M. & Simeone, D. M. Pancreatic cancer: pathogenesis, screening, diagnosis, and treatment. Gastroenterology 163, 386–402 (2022).

    Article 
    PubMed 

    Google Scholar
     

  • Binenbaum, Y., Na’ara, S. & Gil, Z. Gemcitabine resistance in pancreatic ductal adenocarcinoma. Drug Resist. Updat. 23, 55–68 (2015).

    Article 
    PubMed 

    Google Scholar
     

  • Ho, W. J., Jaffee, E. M. & Zheng, L. The tumour microenvironment in pancreatic cancer—clinical challenges and opportunities. Nat. Rev. Clin. Oncol. 17, 527–540 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sherman, M. H. & Beatty, G. L. Tumor microenvironment in pancreatic cancer pathogenesis and therapeutic resistance. Annu. Rev. Pathol. 18, 123–148 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Magnon, C. et al. Autonomic nerve development contributes to prostate cancer progression. Science 341, 1236361 (2013).

    Article 
    PubMed 

    Google Scholar
     

  • Amit, M. et al. Loss of p53 drives neuron reprogramming in head and neck cancer. Nature 578, 449–454 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang, Y. et al. Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies. Cell Metab. 34, 1999–2017 (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Banh, R. S. et al. Neurons release serine to support mRNA translation in pancreatic cancer. Cell 183, 1202–1218 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Renz, B. W. et al. β2 adrenergic-neurotrophin feedforward loop promotes pancreatic cancer. Cancer Cell 33, 75–90 (2018).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Demir, I. E., Friess, H. & Ceyhan, G. O. Neural plasticity in pancreatitis and pancreatic cancer. Nat. Rev. Gastroenterol. Hepatol. 12, 649–659 (2015).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Hanahan, D. & Monje, M. Cancer hallmarks intersect with neuroscience in the tumor microenvironment. Cancer Cell 41, 573–580 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jurcak, N. R. et al. Axon guidance molecules promote perineural invasion and metastasis of orthotopic pancreatic tumors in mice. Gastroenterology 157, 838–850 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Deshpande, K. et al. Neuronal exposure induces neurotransmitter signaling and synaptic mediators in tumors early in brain metastasis. Neuro Oncol. 24, 914–924 (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Cervantes-Villagrana, R. D., Albores-García, D., Cervantes-Villagrana, A. R. & García-Acevez, S. J. Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies. Signal Transduct. Target. Ther. 5, 99 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Khanmammadova, N., Islam, S., Sharma, P. & Amit, M. Neuro-immune interactions and immuno-oncology. Trends Cancer 9, 636–649 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li, J., Kang, R. & Tang, D. Cellular and molecular mechanisms of perineural invasion of pancreatic ductal adenocarcinoma. Cancer Commun. 41, 642–660 (2021).

    Article 

    Google Scholar
     

  • Sugimoto, M. et al. Prognostic impact of M2 macrophages at neural invasion in patients with invasive ductal carcinoma of the pancreas. Eur. J. Cancer 50, 1900–1908 (2014).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zahalka, A. H. et al. Adrenergic nerves activate an angio-metabolic switch in prostate cancer. Science 358, 321–326 (2017).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chang, A. et al. Beta-blockade enhances anthracycline control of metastasis in triple-negative breast cancer. Sci. Transl. Med. 15, eadf1147 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Huang, E. J. & Reichardt, L. F. Trk receptors: roles in neuronal signal transduction. Annu. Rev. Biochem. 72, 609–642 (2003).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Nakagawara, A. Trk receptor tyrosine kinases: a bridge between cancer and neural development. Cancer Lett. 169, 107–114 (2001).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • O’Keeffe, G. W., Gutierrez, H., Pandolfi, P. P., Riccardi, C. & Davies, A. M. NGF-promoted axon growth and target innervation requires GITRL-GITR signaling. Nat. Neurosci. 11, 135–142 (2008).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Silverman, D. A. et al. Cancer-associated neurogenesis and nerve–cancer cross-talk. Cancer Res. 81, 1431–1440 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Allen, J. K. et al. Sustained adrenergic signaling promotes intratumoral innervation through BDNF induction. Cancer Res. 78, 3233–3242 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hong, D. S. et al. Larotrectinib in patients with TRK fusion-positive solid tumours: a pooled analysis of three phase 1/2 clinical trials. Lancet Oncol. 21, 531–540 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu, D. et al. Characterization of on-target adverse events caused by TRK inhibitor therapy. Ann. Oncol. 31, 1207–1215 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Jahromi, L. P. & Fuhrmann, G. Bacterial extracellular vesicles: understanding biology promotes applications as nanopharmaceuticals. Adv. Drug Deliv. Rev. 173, 125–140 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Li, M. et al. Bacterial outer membrane vesicles as a platform for biomedical applications: an update. J. Control. Release 323, 253–268 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhuang, W. R. et al. Bacterial outer membrane vesicle based versatile nanosystem boosts the efferocytosis blockade triggered tumor-specific immunity. Nat. Commun. 14, 1675 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Toyofuku, M., Schild, S., Kaparakis-Liaskos, M. & Eberl, L. Composition and functions of bacterial membrane vesicles. Nat. Rev. Microbiol. 21, 415–430 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wei, B. et al. Polarization of tumor-associated macrophages by nanoparticle-loaded Escherichia coli combined with immunogenic cell death for cancer immunotherapy. Nano Lett. 21, 4231–4240 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Qin, J. et al. Bacterial outer membrane vesicle-templated biomimetic nanoparticles for synergistic photothermo-immunotherapy. Nano Today 46, 101591 (2022).

    Article 
    CAS 

    Google Scholar
     

  • Puurunen, M. K. et al. Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study. Nat. Metab. 3, 1125–1132 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Whitney, M. A. et al. Fluorescent peptides highlight peripheral nerves during surgery in mice. Nat. Biotechnol. 29, 352–356 (2011).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • You, H. et al. Sight and switch off: nerve density visualization for interventions targeting nerves. Sci. Adv. 6, eaax6040 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kaduri, M. et al. Targeting neurons in the tumor microenvironment with bupivacaine nanoparticles reduces breast cancer progression and metastases. Sci. Adv. 7, eabj5435 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Madeo, M. et al. Cancer exosomes induce tumor innervation. Nat. Commun. 9, 4284 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Tian, Z. et al. TIMP1 derived from pancreatic cancer cells stimulates Schwann cells and promotes the occurrence of perineural invasion. Cancer Lett. 546, 215863 (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Gysler, S. M. & Drapkin, R. Tumor innervation: peripheral nerves take control of the tumor microenvironment. J. Clin. Invest. 131, e147276 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Arnaoutova, I. & Kleinman, H. K. In vitro angiogenesis: endothelial cell tube formation on gelled basement membrane extract. Nat. Protoc. 5, 628–635 (2010).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Feng, Q. et al. Engineered bacterial outer membrane vesicles as controllable two-way adaptors to activate macrophage phagocytosis for improved tumor immunotherapy. Adv. Mater. 34, 2206200 (2022).

    Article 
    CAS 

    Google Scholar
     

  • Borsini, A., Zunszain, P. A., Thuret, S. & Pariante, C. M. The role of inflammatory cytokines as key modulators of neurogenesis. Trends Neurosci. 38, 145–157 (2015).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Neumann, H. et al. Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a rho-dependent mechanism. J. Neurosci. 22, 854–862 (2002).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wei, Z. et al. Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles. Nat. Commun. 12, 440 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chu, X. et al. Blocking cancer–nerve crosstalk for treatment of metastatic bone cancer pain. Adv. Mater. 34, 2108653 (2022).

    Article 
    CAS 

    Google Scholar
     

  • Malin, S. A., Davis, B. M. & Molliver, D. C. Production of dissociated sensory neuron cultures and considerations for their use in studying neuronal function and plasticity. Nat. Protoc. 2, 152–160 (2007).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Martinez-Jothar, L. et al. Insights into maleimide-thiol conjugation chemistry: conditions for efficient surface functionalization of nanoparticles for receptor targeting. J. Control. Release 282, 101–109 (2018).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wang, Z. et al. Immunogenic camptothesome nanovesicles comprising sphingomyelin-derived camptothecin bilayers for safe and synergistic cancer immunochemotherapy. Nat. Nanotechnol. 16, 1130–1140 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • RELATED ARTICLES

    LEAVE A REPLY

    Please enter your comment!
    Please enter your name here

    - Advertisment -
    Google search engine

    Most Popular

    Recent Comments